Substitution at R3 with a halogen or alkoxy group (74f–74i) triggered a slight boost in mobile potency Using the halide analogs (74g–h) showing highest the potency during the group. Even further optimization resulted in the invention of 74i–j, with 74k as the most active compound in the sequence (pIC50 = https://fernandofbrgv.azzablog.com/31571756/5-essential-elements-for-indazole-drugs