There is in fact no highway that accesses Aguas Calientes from Cusco, so using a bus for the entire journey isn't a possibility. The trains are your best wager! Luckily for us, when you’re heading to Cusco, there are several tours to Machu Picchu that make preparing much more simple. https://machupicchuhikingtoursfro51593.bloggactivo.com/26340726/the-ultimate-guide-to-machu-picchu-tours