Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators through the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interact... https://lloydd466lja1.wizzardsblog.com/profile