Epidural clonidine utilized as an adjunct to local anesthetics has 3 unique mechanisms of action. To start with, the stimulation of alpha-two-receptors inside the dorsal horn decreases pain transmission. Secondly, clonidine could potentially cause local vasoconstriction that restrictions vascular removing of nearby epidural anesthetics. Jun 10, 2024 · If https://werners749pff3.wikijm.com/user